It is thought that penile cancer is a preventable disease since there are wide variations in the incidence of this cancer around the world. In general, it is best to avoid the known risk factors mentioned previously. Reducing the chance of developing penile cancer includes avoiding sexual practices that are likely to result in human papillomavirus infection, limiting the number of sexual partners, and quitting smoking. In addition, practicing good genital hygiene by retracting the foreskin (in uncircumcised men) and cleaning the entire penis is important since some, but not all, studies suggest that a substance called smegma could contain cancer-causing elements.
It is still questionable whether circumcision reduces the risk of developing penile cancer; especially since penile cancer risk is low in some uncircumcised populations.